The main purpose of this research project is to identify the component(s) in milk leading to enhanced expression of ‘the fasting-induced adipose factor’ (FIAF) and to elucidate the mechanisms by which FIAF-inducing milk component(s) may regulate body weight and energy homeostasis, using animal and human intervention studies.

Recent studies have indicated that milk and milk products, may regulate energy uptake and expenditure. In preliminary experiments, we have provided evidence for a novel mechanism by which milk may regulate body weight by showing the presence of components in milk that enhance the expression of the so-called fasting-induced adipose factor. Increased levels of FIAF in circulation have been shown to reduce lipid uptake in target organs by inhibiting lipoprotein lipase.

 

Project period: January 1. 2011 to December 31. 2015.