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Size-exclusion chromatography with multi-angle light scattering WYATT and Agilent

  • SEC-MALS determines molecular weight from 200 g/mol . radius of gyration Rg  – from 10 nm to 500 nm
  • It can assess molecular conformation  of peptides, proteins, conjugates, biopolymers
  • Mals detector coupled to size exclusion chromatography eliminates the uncertainty and hassle of column calibration, for true confidence in macromolecular characterization
  • Complex macromolecules may not be accessible at all to standard SEC analysis. SEC-MALS readily characterizes many of these, providing information beyond molar mass and size