Size-exclusion chromatography with multi-angle light scattering WYATT and Agilent
- SEC-MALS determines molecular weight from 200 g/mol . radius of gyration Rg – from 10 nm to 500 nm
- It can assess molecular conformation of peptides, proteins, conjugates, biopolymers
- Mals detector coupled to size exclusion chromatography eliminates the uncertainty and hassle of column calibration, for true confidence in macromolecular characterization
- Complex macromolecules may not be accessible at all to standard SEC analysis. SEC-MALS readily characterizes many of these, providing information beyond molar mass and size
